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  • Some antidepressants can help to reduce hot flushes. Certain options are preferred for example, for women taking aromatase inhibitors (AIs) such as tamoxifen (a breast cancer drug), where it can reduce hot flushes and also improve fatigue, mental health and sleep disturbance.

    Antidepressants may take six to eight weeks to have the full effects; however improvement is often seen within one to three weeks, but some women experience side effects, such as nausea, dizziness, fatigue and changes in sexual function, that mean they stop taking the treatment.

    Anticonvulsants originally used to treat epilepsy has been found to help with hot flushes. They are started at a low dose and increased gradually to monitor for side effects

    Antihypertensives (blood pressure drugs) have also been found to help with hot flushes.

    These are started at a lower dose, as at higher doses it sometimes disrupts sleep

    These prescription treatments may be worth discussing if other treatment options aren’t able to provide relief.

PP-UN-WHC-GB-0222 July 2025